How to Prevent Pertussis?

(A) isolate the source of infection for the patients respiratory isolation strict implementation of the important aspects of prevention. Isolation period began from the onset, a period of seven weeks; cough spasm began a period of four weeks. Close contact with susceptible children (especially in collective bodies) need to quarantine three weeks. Adult patients should pay attention to avoid contact with children. The foci Just ventilation.

(B) protect susceptible

Active immunization used DPT (DPT, diphtheria toxoid, pertussis vaccine, tetanus toxoid) DPT immunization of infants 3 to 6 months of birth, the subcutaneous injection three times. Epidemic period, a children can be vaccinated. Emphasize the full immunization, and then after provisions to strengthen. The pertussis vaccine even can cause encephalopathy and other neurological reaction, so the original brain disorders or convulsive disorders, or after the first dose of pertussis vaccine had convulsions, that any should be re-injected. JE epidemic season nor pertussis vaccination. Current whole-cell pertussis vaccine has played a certain role, but the effect is still not ideal, children and adult-onset immune after suffering from whooping cough frequently reported.

Acellular pertussis vaccines: use some part of Bordetella pertussis, and not made with whole Bordetella pertussis pertussis vaccine, the protective effect compared with the whole-cell pertussis vaccine, while avoiding the side effects of the whole-cell vaccine. 1981 Sato to pertussis toxin (Pertussiu Toxin PT) and filamentous hemagglutinin (Filamentous hemagglutmin FHA) as a main component acellular pertussis vaccine to be successful. Britain and the United States, Sweden and other countries subsequently developed various acellular pertussis component of the vaccine used to crowd the most was the effect. Has confirmed regardless of acellular pertussis component vaccine, pertussis toxin (PT) antigen is an essential component. Further study reveals that the pertussis toxin (PT-McAb) monoclonal antibody has the characteristics of the specificity and pertussis toxin in vitro and in vivo in a variety of biological activity, and also has a defensive role in the protection of Bordetella pertussis infection.

2 passive immunization of infants or infirm, in contact with patients to pertussis high titers of immunoglobulin, but the effect is to prevent and alleviate the symptoms does not significantly so few applications.

(C) drug prevention baby after contact with the patient, to erythromycin daily 50mg/kg orally 4 times, once every 10 to 14 days, the better.

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